Peripheral nervous system myelin maintenance

Across TCGA patient cohorts, RNA activity of the Peripheral nervous system myelin maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THBS2, AKT1S1_T246, and THBS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peripheral nervous system myelin maintenance activity versus THBS2 in OV (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	THBS2 →	+0.789	+0.067	.005	<.001	3	4
OV	AKT1S1_T246 →	+0.894	+0.086	<.001	.001	3	4
GBM	THBS1 →	+0.769	+0.066	.004	.004	3	4
GBM	LOX →	+0.484	+0.052	.007	.002	3	4
GBM	CIT →	-0.357	-0.066	.006	.003	3	4
GBM	PLOD1 →	+0.515	+0.082	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032287 vs THBS2 — OV

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