Peripheral nervous system myelin maintenance

Across TCGA pan-cancer cohorts, RNA activity of the Peripheral nervous system myelin maintenance pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Peripheral nervous system myelin maintenance pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as MESO and UCS, show the opposite pattern, with higher activity associated with better survival.

KIRC, UCEC, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.544	0.692	<.001	76	view →
UCEC	OS	Median	All	0.597	0.744	<.001	72	view →
ACC	DFS	Median	All	0.515	0.776	.001	70	view →
MESO	DFS	Tertile	III,IV	0.488	0.246	.001	40	view →
UCS	DFS	Tertile	III,IV	0.622	0.270	.017	26	view →
PRAD	DFS	Tertile	All	0.673	0.870	.001	24	view →
UVM	OS	Median	All	0.853	0.502	.014	16	view →
READ	DFS	Median	All	0.900	0.578	.001	13	view →
LGG	DFS	Tertile	All	0.647	0.782	.002	10	view →
SKCM	OS	Tertile	IV	1.000	0.211	.013	9	view →
THCA	DFS	Median	All	0.907	0.706	.020	9	view →
KICH	OS	Quartile	II,III,IV	1.000	0.498	.005	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0032287–KIRC (DFS)

Open the KIRC breakdown →