Peripheral nervous system myelin maintenance

Across TCGA patient cohorts, RNA activity of the Peripheral nervous system myelin maintenance pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP10, HRH1, and ITGA3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peripheral nervous system myelin maintenance activity versus MMP10 in LSCC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MMP10 →	+2.258	+0.660	<.001	.005	3	6
LSCC	HRH1 →	+0.736	+0.678	<.001	.005	3	6
BRCA	ITGA3 →	+1.104	+0.476	.001	.006	2	7
HNSC	SCML2 →	-0.762	-0.314	.001	<.001	3	6
LSCC	LGALS1 →	+0.986	+0.808	<.001	<.001	3	5
HNSC	MYEF2 →	-1.178	-0.464	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032287 vs MMP10 — LSCC

Explore this scatter interactively →