Peripheral nervous system myelin maintenance

Across TCGA cell cohorts, RNA activity of the Peripheral nervous system myelin maintenance pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBA1A, CD47, and EMP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUBA1A grouped by Peripheral nervous system myelin maintenance-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TUBA1A →	-2.759	-0.700	.005	.007	3	4
BREAST	CD47 →	+1.097	+0.731	<.001	.004	3	3
UPPER_AERODIGESTIVE_TRACT	EMP2 →	+1.892	+0.247	.003	.008	3	3
BLOOD_Lymphoma	SYNGR1 →	-4.464	-1.789	<.001	<.001	3	3
BLOOD_Lymphoma	ARSB →	+2.495	+2.062	.001	.003	3	3
BLOOD_Lymphoma	RDX →	+4.585	+2.062	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUBA1A by Peripheral nervous system myelin maintenance activity — STOMACH

Explore this box plot interactively →