Peripheral nervous system myelin maintenance

Across TCGA cell cohorts, RNA activity of the Peripheral nervous system myelin maintenance pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF3H, WDR90, and GINM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF3H grouped by Peripheral nervous system myelin maintenance-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EIF3H →	-0.298	-0.156	.001	.002	3	5
BLOOD_Myeloma	WDR90 →	-0.330	-0.272	.007	.001	3	4
BONE	GINM1 →	+0.631	+0.418	.008	.003	3	4
SOFT_TISSUE	RAPGEF6 →	+0.387	+0.215	<.001	.002	3	4
SOFT_TISSUE	KCNS2 →	+0.232	+0.289	<.001	.003	3	4
SOFT_TISSUE	IRAK1 →	-0.280	-0.234	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF3H by Peripheral nervous system myelin maintenance activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →