Peripheral nervous system myelin maintenance

Across TCGA cell cohorts, RNA activity of the Peripheral nervous system myelin maintenance pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL1RAP, ZNF268, and BCL2L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peripheral nervous system myelin maintenance activity versus IL1RAP in BLOOD_Leukemia (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IL1RAP →	+1.023	+0.336	.002	.002	3	4
CNS	ZNF268 →	-0.758	-0.118	.003	.004	3	4
KIDNEY	BCL2L1 →	-1.043	-0.293	.009	.001	3	4
LUNG_NSCLC_LUSC	STK11 →	-0.830	-0.180	.001	.001	3	3
LUNG_NSCLC_LUSC	ZSCAN5A →	-0.759	-0.180	.001	.001	3	3
LUNG_NSCLC_LUSC	DGKZ →	-0.631	-0.180	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032287 vs IL1RAP — BLOOD_Leukemia

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