Gonadotropin secretion

Across TCGA patient cohorts, RNA activity of the Gonadotropin secretion pathway is significantly associated with the RNA expression of multiple genes, with the READ cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INHBB, NID1, and FSTL1, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gonadotropin secretion activity versus INHBB in READ (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	INHBB →	+1.415	+0.062	<.001	<.001	3	25
TGCT	NID1 →	+2.025	+0.100	<.001	<.001	3	24
MESO	FSTL1 →	+1.214	+0.053	<.001	<.001	3	24
MESO	COL4A1 →	+1.621	+0.051	.001	.002	2	25
TGCT	NID2 →	+1.624	+0.067	<.001	<.001	3	24
TGCT	FLT1 →	+0.936	+0.071	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032274 vs INHBB — READ

Explore this scatter interactively →