Gonadotropin secretion

Across TCGA patient cohorts, RNA activity of the Gonadotropin secretion pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GJA1, KCTD11, and TMEM144, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gonadotropin secretion activity versus GJA1 in OV (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GJA1 →	+1.572	+0.858	<.001	<.001	3	5
HNSC	KCTD11 →	+0.663	+0.395	<.001	<.001	3	5
GBM	TMEM144 →	+1.171	+0.340	.001	<.001	3	4
BRCA	CYB5R1 →	+0.672	+0.885	<.001	<.001	3	4
GBM	CDC25A →	-1.003	-0.390	<.001	<.001	3	4
HNSC	GJB2 →	+1.144	+0.366	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032274 vs GJA1 — OV

Explore this scatter interactively →