IMP salvage

Across TCGA patient cohorts, RNA activity of the IMP salvage pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGHG2, JCHAIN, and IGKV6-21, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IMP salvage activity versus IGHG2 in SKCM (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	IGHG2 →	-2.947	-0.066	<.001	<.001	3	24
SKCM	JCHAIN →	-2.578	-0.059	<.001	<.001	3	23
TGCT	IGKV6-21 →	-2.250	-0.070	<.001	<.001	3	23
SKCM	IGLV3-21 →	-2.979	-0.061	<.001	<.001	3	23
SKCM	IGLC2 →	-3.085	-0.066	<.001	<.001	3	23
TGCT	IGLC3 →	-3.240	-0.084	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032264 vs IGHG2 — SKCM

Explore this scatter interactively →