Secretory granule localization

Across TCGA patient cohorts, RNA activity of the Secretory granule localization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP2, GRAP2, and P4HA1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Secretory granule localization activity versus MAP2 in LUAD (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MAP2 →	+0.631	+0.051	<.001	<.001	3	7
HNSC	GRAP2 →	+0.566	+0.078	<.001	<.001	3	6
PDAC	P4HA1 →	-0.403	-0.045	.002	.001	3	6
BRCA	CORO1A →	+0.382	+0.029	.004	.007	3	5
BRCA	AMPD3 →	+0.277	+0.029	<.001	<.001	3	5
HNSC	AGO2 →	-0.172	-0.063	.001	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032252 vs MAP2 — LUAD

Explore this scatter interactively →