Secretory granule localization

Across TCGA cell cohorts, RNA activity of the Secretory granule localization pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MECP2, PIK3CG, and KIF1A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MECP2 grouped by Secretory granule localization-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MECP2 →	-0.583	-1.598	<.001	<.001	3	9
BLOOD_Myeloma	PIK3CG →	-0.532	-1.980	.002	<.001	3	6
LARGE_INTESTINE	KIF1A →	-0.196	-0.902	<.001	<.001	3	6
SOFT_TISSUE	PUDP →	-0.327	-1.326	.008	.003	3	5
SOFT_TISSUE	GJB4 →	-0.356	-1.227	.003	.002	3	5
OESOPHAGUS	UBL5 →	+0.348	+1.400	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MECP2 by Secretory granule localization activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →