Adenosine transport

Across TCGA patient cohorts, RNA activity of the Adenosine transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIT1_S455, UNG, and FAM76B_T215, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenosine transport activity versus TRIT1_S455 in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRIT1_S455 →	+0.517	+0.077	<.001	<.001	3	5
LSCC	UNG →	+0.633	+0.089	<.001	<.001	3	5
LUAD	FAM76B_T215 →	+0.879	+0.077	.002	.001	3	5
HNSC	RBBP5_S497 →	+0.684	+0.075	<.001	<.001	3	5
LSCC	RBM17 →	+0.205	+0.082	.005	<.001	3	5
LSCC	UBR5 →	+0.149	+0.059	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032238 vs TRIT1_S455 — LSCC

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