Positive regulation of actin filament bundle assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of actin filament bundle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN1, TBC1D2B, and DAB2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of actin filament bundle assembly activity versus TLN1 in COAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TLN1 →	+0.360	+0.032	<.001	<.001	3	10
GBM	TBC1D2B →	+0.399	+0.055	<.001	<.001	3	9
GBM	DAB2 →	+0.688	+0.052	<.001	<.001	3	9
CCRCC	PALM2AKAP2 →	+0.649	+0.056	<.001	<.001	3	9
COAD	RSU1 →	+0.419	+0.038	<.001	<.001	3	9
UCEC	SORBS3 →	+0.426	+0.048	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032233 vs TLN1 — COAD

Explore this scatter interactively →