Negative regulation of actin filament bundle assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of actin filament bundle assembly pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE1A, ZCCHC24, and TRPC6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of actin filament bundle assembly activity versus PDE1A in OV (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PDE1A →	+1.204	+0.410	<.001	.006	3	5
OV	ZCCHC24 →	+0.989	+0.405	<.001	<.001	3	5
LUAD	TRPC6 →	+0.671	+0.762	.001	.001	3	5
BRCA	GPIHBP1 →	+0.884	+0.520	<.001	.004	3	5
CCRCC	COX4I2 →	+1.035	+0.865	.002	.002	3	4
CCRCC	TMEM204 →	+0.780	+0.703	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032232 vs PDE1A — OV

Explore this scatter interactively →