Negative regulation of actin filament bundle assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of actin filament bundle assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAL2, PATJ, and TMEM265, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of actin filament bundle assembly activity versus MAL2 in BREAST (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAL2 →	+4.154	+0.270	<.001	.001	3	9
BREAST	PATJ →	+1.392	+0.249	.002	<.001	2	8
STOMACH	TMEM265 →	+2.962	+0.393	<.001	<.001	3	7
LUNG_NSCLC_LUAD	PRSS22 →	+3.191	+0.302	<.001	<.001	3	7
BREAST	SLC35B4 →	-1.187	-0.262	.002	.003	3	7
LUNG_NSCLC_LUAD	FUT1 →	+0.939	+0.223	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032232 vs MAL2 — BREAST

Explore this scatter interactively →