Regulation of actin filament bundle assembly

Across TCGA cell cohorts, RNA activity of the Regulation of actin filament bundle assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDXP, CNKSR1, and HSH2D, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of actin filament bundle assembly activity versus PDXP in STOMACH (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PDXP →	-1.157	-0.317	.004	.002	3	8
STOMACH	CNKSR1 →	+2.600	+0.313	.001	.001	3	7
BLOOD_Myeloma	HSH2D →	+4.724	+0.366	<.001	<.001	3	7
OVARY	PPP1R13L →	+2.138	+0.291	<.001	<.001	3	7
BONE	UNC93B1 →	+2.203	+0.312	.003	<.001	3	7
OVARY	PRRG4 →	+2.027	+0.288	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032231 vs PDXP — STOMACH

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