"Regulation of synaptic transmission, GABAergic"

Across TCGA patient cohorts, RNA activity of the "Regulation of synaptic transmission, GABAergic" pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF704, CHCHD4P4, and RHOT1P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of synaptic transmission, GABAergic" activity versus ZNF704 in CCRCC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZNF704 →	+0.758	+0.591	.006	.009	3	4
UCEC	CHCHD4P4 →	+0.788	+0.734	<.001	.002	3	4
LUAD	RHOT1P1 →	+0.599	+0.722	.002	<.001	3	4
PDAC	CBX1P2 →	-0.553	-0.654	.006	.003	3	4
GBM	TUBB4A →	+2.096	+1.067	<.001	<.001	3	3
GBM	PLCL1 →	+1.029	+0.676	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032228 vs ZNF704 — CCRCC

Explore this scatter interactively →