"Regulation of synaptic transmission, dopaminergic"

Across TCGA cell cohorts, RNA activity of the "Regulation of synaptic transmission, dopaminergic" pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG14, NUPR1, and CMTM6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATG14 grouped by "Regulation of synaptic transmission, dopaminergic"-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ATG14 →	-1.300	-1.272	.007	.001	3	4
LUNG_NSCLC_LUAD	NUPR1 →	+1.911	+0.604	.003	.009	3	4
LUNG_NSCLC_LUAD	CMTM6 →	-0.970	-1.120	<.001	<.001	3	4
KIDNEY	PNPO →	+0.918	+1.420	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	NEMF →	-1.466	-1.332	.005	.001	3	4
LIVER	WDR89 →	-0.555	-2.168	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATG14 by "Regulation of synaptic transmission, dopaminergic" activity — UPPER_AERODIGESTIVE_TRACT

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