"Positive regulation of synaptic transmission, cholinergic"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of synaptic transmission, cholinergic" pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP12_S806, VCL, and DPYSL2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of synaptic transmission, cholinergic" activity versus AKAP12_S806 in PDAC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	AKAP12_S806 →	+0.640	+0.048	<.001	<.001	3	7
LSCC	VCL →	+0.291	+0.056	.001	.005	3	7
COAD	DPYSL2 →	+0.452	+0.124	<.001	<.001	3	6
PDAC	RSU1 →	+0.321	+0.067	<.001	<.001	3	6
PDAC	LAMA2 →	+0.440	+0.040	<.001	<.001	3	6
PDAC	PDE3A →	+0.380	+0.054	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032224 vs AKAP12_S806 — PDAC

Explore this scatter interactively →