"Positive regulation of synaptic transmission, cholinergic"

Across TCGA pan-cancer cohorts, RNA activity of the "Positive regulation of synaptic transmission, cholinergic" pathway differs between tumor and matched normal tissue in 14 of the 18 cancer types tested.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as BLCA and HNSC, show the opposite pattern, with lower activity in tumor tissue.

BLCA, HNSC, and KIRC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
BLCA	Male	All	−0.243	<.001	11	view →
HNSC	Male	IV	−0.099	<.001	8	view →
KIRC	All	II,III,IV	−0.027	.003	8	view →
UCEC	All	All	−0.376	<.001	6	view →
STAD	All	II,III,IV	−0.146	<.001	6	view →
BRCA	All	II,III,IV	−0.108	<.001	6	view →
LUSC	Male	II,III,IV	−0.071	<.001	6	view →
LUAD	Female	All	−0.058	<.001	6	view →
COAD	All	All	−0.060	<.001	5	view →
KIRP	All	All	−0.227	.019	3	view →
THCA	All	All	−0.123	.011	3	view →
PRAD	All	All	−0.031	.018	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 14 lineages.

GO:0032224–BLCA

Open the BLCA breakdown →