"Positive regulation of synaptic transmission, cholinergic"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of synaptic transmission, cholinergic" pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF4, ADAMTSL5, and PAX5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of synaptic transmission, cholinergic" activity versus IRF4 in GBM (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IRF4 →	+0.425	+0.605	.003	<.001	3	3
BRCA	ADAMTSL5 →	-1.980	-0.404	.002	.006	3	3
BRCA	PAX5 →	+1.099	+0.387	<.001	<.001	3	3
GBM	GRK3 →	+0.578	+0.740	<.001	.001	3	2
GBM	PIK3IP1 →	+0.654	+0.513	.001	.002	3	2
GBM	LGMN →	+0.477	+0.410	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032224 vs IRF4 — GBM

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