Negative regulation of telomere maintenance via telomerase

Across TCGA patient cohorts, RNA activity of the Negative regulation of telomere maintenance via telomerase pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXM1, MTFR2, and RAD54B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of telomere maintenance via telomerase activity versus FOXM1 in UCEC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXM1 →	+0.908	+0.148	<.001	.002	3	6
UCEC	MTFR2 →	+0.550	+0.136	.002	<.001	3	6
HNSC	RAD54B →	+0.652	+0.120	<.001	.005	3	6
UCEC	RAD51AP1 →	+0.799	+0.134	<.001	.005	3	5
GBM	LMNB1 →	+0.840	+0.200	.001	<.001	3	5
UCEC	NCAPH →	+0.645	+0.186	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032211 vs FOXM1 — UCEC

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