Negative regulation of telomere maintenance

Across TCGA cell cohorts, RNA activity of the Negative regulation of telomere maintenance pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FDXR, COL3A1, and CCN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FDXR grouped by Negative regulation of telomere maintenance-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FDXR →	-1.535	-0.257	<.001	<.001	3	6
BLOOD_Leukemia	COL3A1 →	+0.262	+0.232	.003	<.001	3	5
BREAST	CCN1 →	+3.128	+0.210	<.001	<.001	3	4
BREAST	NUAK1 →	+0.796	+0.123	.008	.003	3	4
LUNG_NSCLC_LUSC	FUBP3 →	+0.490	+0.207	.002	<.001	3	4
LUNG_SCLC	STAT3 →	+1.393	+0.217	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FDXR by Negative regulation of telomere maintenance activity — CNS

Explore this box plot interactively →