Regulation of telomere maintenance

Across TCGA cell cohorts, RNA activity of the Regulation of telomere maintenance pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CGN, C10orf143, and AFF4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of telomere maintenance activity versus CGN in BLOOD_Leukemia (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CGN →	-0.905	-0.126	<.001	<.001	3	6
BLOOD_Leukemia	C10orf143 →	-0.944	-0.137	.001	.004	3	4
BLOOD_Leukemia	AFF4 →	-0.919	-0.176	<.001	<.001	3	4
BLOOD_Leukemia	GSK3B →	-1.081	-0.197	<.001	<.001	3	4
BLOOD_Leukemia	KIF27 →	-0.937	-0.161	.001	.002	3	4
LIVER	FAM227A →	-0.828	-0.228	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032204 vs CGN — BLOOD_Leukemia

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