Telomere maintenance via semi-conservative replication

Across TCGA patient cohorts, RNA activity of the Telomere maintenance via semi-conservative replication pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRC1, RFC1_S368, and RFC2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere maintenance via semi-conservative replication activity versus PRC1 in PDAC (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PRC1 →	+0.586	+0.066	.001	<.001	3	10
LUAD	RFC1_S368 →	+0.779	+0.084	<.001	<.001	3	9
HNSC	RFC2 →	+0.494	+0.081	<.001	<.001	3	9
LSCC	RFC4 →	+0.381	+0.047	<.001	<.001	3	9
LUAD	RPL12_S38 →	+0.856	+0.070	<.001	<.001	3	9
LUAD	RRM2 →	+0.746	+0.084	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032201 vs PRC1 — PDAC

Explore this scatter interactively →