Telomere maintenance via semi-conservative replication

Across TCGA patient cohorts, RNA activity of the Telomere maintenance via semi-conservative replication pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SKA3, VRK1, and E2F1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere maintenance via semi-conservative replication activity versus SKA3 in LSCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SKA3 →	+0.811	+0.595	<.001	<.001	3	7
GBM	VRK1 →	+0.467	+0.116	<.001	.002	3	6
LSCC	E2F1 →	+0.834	+0.628	<.001	<.001	3	6
LSCC	EXO1 →	+0.761	+0.532	.001	.002	3	6
LSCC	MCM10 →	+0.771	+0.515	<.001	.001	3	6
BRCA	KIF4A →	+0.783	+0.493	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032201 vs SKA3 — LSCC

Explore this scatter interactively →