Telomere organization

Across TCGA patient cohorts, RNA activity of the Telomere organization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUPT16H, HDAC2, and MAD2L1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere organization activity versus SUPT16H in LSCC (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SUPT16H →	+0.419	+0.054	<.001	<.001	3	8
HNSC	HDAC2 →	+0.353	+0.098	<.001	.001	3	8
LUAD	MAD2L1 →	+0.352	+0.027	<.001	<.001	3	8
LUAD	MCM2 →	+0.791	+0.045	<.001	<.001	3	8
LUAD	MCM3 →	+0.814	+0.043	<.001	<.001	3	8
LUAD	MCM4 →	+0.823	+0.043	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032200 vs SUPT16H — LSCC

Explore this scatter interactively →