Transposition

Across TCGA patient cohorts, RNA activity of the Transposition pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RNF213, STAT1, and WARS1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transposition activity versus RNF213 in PDAC (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RNF213 →	+0.384	+0.036	<.001	<.001	3	8
UCEC	STAT1 →	+0.572	+0.060	<.001	<.001	3	8
HNSC	WARS1 →	+0.635	+0.044	<.001	<.001	3	8
BRCA	GBP1 →	+0.703	+0.046	<.001	<.001	3	8
CCRCC	GBP5 →	+0.858	+0.052	<.001	.001	3	8
HNSC	ISG20 →	+0.542	+0.031	<.001	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032196 vs RNF213 — PDAC

Explore this scatter interactively →