Transposition

Across TCGA cell cohorts, RNA activity of the Transposition pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSORS1C2, DRAM1, and ACAA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSORS1C2 grouped by Transposition-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PSORS1C2 →	+0.164	+1.625	.008	.003	3	4
CNS	DRAM1 →	+3.534	+2.409	.006	.005	3	3
SOFT_TISSUE	ACAA2 →	-1.097	-1.351	.006	.001	3	3
SOFT_TISSUE	MT-CO3 →	-0.871	-1.842	.003	<.001	3	3
SOFT_TISSUE	FAS →	+2.665	+1.655	.001	<.001	3	3
CNS	IRF2BPL →	+3.205	+2.553	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSORS1C2 by Transposition activity — BLOOD_Lymphoma

Explore this box plot interactively →