Activation of protein kinase activity

Across TCGA patient cohorts, RNA activity of the Activation of protein kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFB9P2, PLK1, and SPOCK3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of protein kinase activity activity versus NDUFB9P2 in LSCC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NDUFB9P2 →	+0.239	+0.620	<.001	.002	3	3
LUAD	PLK1 →	+0.631	+0.617	.001	.002	3	3
LUAD	SPOCK3 →	-0.724	-0.466	<.001	.001	3	3
UCEC	PCNPP5 →	+0.822	+0.724	.006	<.001	3	3
BRCA	MEMO1P3 →	+0.354	+0.335	<.001	.005	3	3
COAD	RPS3AP54 →	+0.115	+0.280	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032147 vs NDUFB9P2 — LSCC

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