Obsolete regulation of response to extracellular stimulus
pathway activity — tumor vs normal
GO:0032104Tumor vs NormalRNA activityBox plot · TCGA cohorts
Across TCGA pan-cancer cohorts, RNA activity of the Obsolete regulation of response to extracellular stimulus pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRC and BRCA, show the opposite pattern, with lower activity in tumor tissue.
KIRC, HNSC, and BRCA show the most reproducible tumor–normal differences in pathway activity.
Tumor vs normal pathway activity by lineage
Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log2 scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.