Regulation of appetite

Across TCGA cell cohorts, RNA activity of the Regulation of appetite pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NENF, ARG1, and TTC33, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of appetite activity versus NENF in BLOOD_Lymphoma (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NENF →	+0.805	+1.327	.006	<.001	3	7
LARGE_INTESTINE	ARG1 →	+0.111	+0.794	<.001	<.001	3	5
STOMACH	TTC33 →	+0.828	+0.795	.008	.003	3	3
KIDNEY	TAGLN2 →	+1.187	+1.715	.002	<.001	3	3
BLOOD_Myeloma	SNHG32 →	-1.702	-0.441	.002	.005	3	3
LARGE_INTESTINE	ATG2A →	-0.716	-0.952	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032098 vs NENF — BLOOD_Lymphoma

Explore this scatter interactively →