Regulation of response to food

Across TCGA patient cohorts, RNA activity of the Regulation of response to food pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP5F1B, MRC2, and RBM47, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to food activity versus ATP5F1B in UCEC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP5F1B →	+0.339	+0.086	<.001	<.001	3	5
UCEC	MRC2 →	-0.416	-0.056	<.001	<.001	3	5
UCEC	RBM47 →	+0.265	+0.050	<.001	.002	3	5
OV	MCAM →	-0.526	-0.064	.001	.002	3	5
OV	NES_S894 →	-1.044	-0.095	.007	.003	3	5
PDAC	EBAG9_S36 →	+0.768	+0.050	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032095 vs ATP5F1B — UCEC

Explore this scatter interactively →