Response to food

Across TCGA patient cohorts, RNA activity of the Response to food pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR19, DHRS3, and CTNNA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to food activity versus WDR19 in CCRCC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	WDR19 →	+0.171	+0.041	<.001	.003	3	5
CCRCC	DHRS3 →	+0.385	+0.038	.005	.007	3	5
HNSC	CTNNA1 →	+0.231	+0.047	.003	.007	3	5
PDAC	CYP51A1 →	+0.350	+0.039	<.001	<.001	3	5
CCRCC	HECTD1 →	-0.186	-0.048	<.001	<.001	3	5
CCRCC	PPP1R18 →	-0.241	-0.035	.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032094 vs WDR19 — CCRCC

Explore this scatter interactively →