Response to food

Across TCGA patient cohorts, RNA activity of the Response to food pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLCCI1, PCOLCE, and PLEC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to food activity versus GLCCI1 in HNSC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GLCCI1 →	-0.752	-0.268	.005	.001	3	4
BRCA	PCOLCE →	+0.876	+0.239	.006	.007	3	4
BRCA	PLEC →	+0.948	+0.300	<.001	.002	3	4
BRCA	KCND2 →	+0.729	+0.205	.005	.002	3	4
LSCC	LGALS1 →	+0.732	+0.580	<.001	.003	3	4
LUAD	COL12A1 →	+1.111	+0.288	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032094 vs GLCCI1 — HNSC

Explore this scatter interactively →