Response to food

Across TCGA cell cohorts, RNA activity of the Response to food pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOLK, MRPS15, and CLN5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DOLK grouped by Response to food-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DOLK →	-0.657	-0.755	.003	.003	3	4
LARGE_INTESTINE	MRPS15 →	+0.576	+1.045	.002	.003	3	4
CNS	CLN5 →	-0.768	-0.985	<.001	.001	3	3
BREAST	THG1L →	+0.653	+0.748	.002	.004	3	3
CNS	ATF4 →	+0.559	+0.985	.005	.001	3	3
BLOOD_Lymphoma	EPO →	-0.095	-1.622	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DOLK by Response to food activity — CNS

Explore this box plot interactively →