Response to food

Across TCGA cell cohorts, RNA activity of the Response to food pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UGT2B17, RGS11, and KPNA5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UGT2B17 grouped by Response to food-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UGT2B17 →	-0.270	-0.298	.001	.006	3	4
KIDNEY	RGS11 →	-0.415	-0.379	.001	.006	3	4
BREAST	KPNA5 →	-0.139	-0.333	<.001	<.001	3	4
OVARY	PCSK4 →	+0.232	+0.304	.003	.004	3	4
OESOPHAGUS	BCL7C →	+0.111	+0.389	.001	<.001	3	3
OVARY	BCL2L1 →	+0.559	+0.265	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UGT2B17 by Response to food activity — LARGE_INTESTINE

Explore this box plot interactively →