Response to food

Across TCGA cell cohorts, RNA activity of the Response to food pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are G6PD, SLC22A5, and CDRT1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to food activity versus G6PD in BREAST (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	G6PD →	+1.680	+0.247	<.001	<.001	3	9
STOMACH	SLC22A5 →	+1.564	+0.402	.004	.006	3	6
OESOPHAGUS	CDRT1 →	+2.315	+0.406	<.001	<.001	3	6
BREAST	DBN1 →	-1.582	-0.337	<.001	<.001	3	5
OVARY	REEP5 →	+0.677	+0.236	.001	.003	2	6
LIVER	OSGIN1 →	+2.987	+0.506	.006	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032094 vs G6PD — BREAST

Explore this scatter interactively →