Negative regulation of protein binding

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein binding pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SP100, SAMHD1, and LCP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein binding activity versus SP100 in LSCC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SP100 →	+0.373	+0.065	<.001	<.001	3	8
BRCA	SAMHD1 →	+0.349	+0.024	<.001	<.001	3	7
BRCA	LCP1 →	+0.483	+0.029	<.001	<.001	3	7
BRCA	LIMD2 →	+0.533	+0.030	<.001	<.001	3	7
GBM	OAS2 →	+0.696	+0.035	<.001	<.001	3	7
LSCC	NAGK →	+0.236	+0.045	.003	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032091 vs SP100 — LSCC

Explore this scatter interactively →