Negative regulation of protein binding

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein binding pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX21, PIGW, and COCH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNX21 grouped by Negative regulation of protein binding-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SNX21 →	-0.635	-0.364	.006	.002	3	4
BLOOD_Leukemia	PIGW →	+0.651	+0.263	.008	.006	3	4
SKIN	COCH →	+0.982	+0.114	.008	.009	3	4
LUNG_SCLC	ZBTB24 →	+0.499	+0.221	.002	.001	3	3
BLOOD_Leukemia	FMR1 →	+0.746	+0.304	.006	.005	3	3
BLOOD_Leukemia	NGDN →	+0.417	+0.333	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNX21 by Negative regulation of protein binding activity — BLOOD_Leukemia

Explore this box plot interactively →