Negative regulation of protein binding

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein binding pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB9, NES, and GDI2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein binding activity versus PSMB9 in LUNG_NSCLC_LUAD (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PSMB9 →	-1.527	-0.205	<.001	.001	3	5
CNS	NES →	+3.687	+0.325	<.001	<.001	3	5
KIDNEY	GDI2 →	+0.804	+0.299	.006	<.001	3	4
LARGE_INTESTINE	LAMTOR2 →	+0.611	+0.232	.001	.002	3	4
LARGE_INTESTINE	CD55 →	-2.089	-0.299	.001	<.001	3	4
OVARY	LAMA3 →	-3.323	-0.236	.002	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032091 vs PSMB9 — LUNG_NSCLC_LUAD

Explore this scatter interactively →