Bleb assembly

Across TCGA cell cohorts, RNA activity of the Bleb assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AXL, EMP1, and EMP3, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bleb assembly activity versus AXL in LUNG_NSCLC_LUSC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AXL →	+4.299	+0.440	<.001	.003	3	15
BONE	EMP1 →	+4.117	+0.326	<.001	<.001	3	15
LIVER	EMP3 →	+4.010	+0.341	<.001	<.001	3	14
LUNG_NSCLC_LUSC	LGALS1 →	+5.094	+0.330	<.001	<.001	3	13
BLOOD_Lymphoma	TIMP1 →	+4.205	+0.501	<.001	.005	2	14
BONE	PMP22 →	+3.141	+0.234	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032060 vs AXL — LUNG_NSCLC_LUSC

Explore this scatter interactively →