Positive regulation of translation in response to stress

Across TCGA patient cohorts, RNA activity of the Positive regulation of translation in response to stress pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF4G1_S1092, STIM1_S567, and LARP1_T299, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of translation in response to stress activity versus EIF4G1_S1092 in COAD (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EIF4G1_S1092 →	+0.725	+0.293	<.001	.001	3	7
UCEC	STIM1_S567 →	+0.828	+0.299	<.001	<.001	3	5
UCEC	LARP1_T299 →	+0.624	+0.193	.004	.004	2	5
PDAC	VCL_S809 →	-0.678	-0.217	<.001	<.001	3	3
BRCA	EIF4B_S406 →	+0.790	+0.424	<.001	.001	3	3
LSCC	EIF4G1_S1238 →	+0.862	+0.307	<.001	.007	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032056 vs EIF4G1_S1092 — COAD

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