Positive regulation of translation in response to stress

Across TCGA cell cohorts, RNA activity of the Positive regulation of translation in response to stress pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC3, TM9SF2, and AP1S1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of translation in response to stress activity versus DNAJC3 in LUNG_NSCLC_LUAD (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DNAJC3 →	+0.980	+0.241	.001	<.001	3	7
CNS	TM9SF2 →	+0.596	+0.167	.004	.004	3	6
KIDNEY	AP1S1 →	-1.267	-0.335	<.001	.001	3	4
BLOOD_Myeloma	PCYOX1L →	-1.481	-0.218	<.001	.005	3	4
BLOOD_Myeloma	SYNM →	-2.201	-0.263	<.001	<.001	3	4
BLOOD_Myeloma	UTP14C →	+1.662	+0.239	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032056 vs DNAJC3 — LUNG_NSCLC_LUAD

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