Cardiolipin metabolic process

Across TCGA patient cohorts, RNA activity of the Cardiolipin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYEF2_S17, ITGA4, and PRUNE1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiolipin metabolic process activity versus MYEF2_S17 in OV (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MYEF2_S17 →	+0.586	+0.037	.003	<.001	3	6
OV	ITGA4 →	-0.497	-0.034	.004	.002	3	6
HNSC	PRUNE1 →	+0.232	+0.045	.001	<.001	3	6
HNSC	LUZP1 →	-0.371	-0.041	<.001	<.001	3	5
LSCC	SART3 →	+0.213	+0.040	.009	.001	3	5
OV	ZEB2 →	-0.378	-0.038	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032048 vs MYEF2_S17 — OV

Explore this scatter interactively →