Cardiolipin metabolic process

Across TCGA patient cohorts, RNA activity of the Cardiolipin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOXB13, SH3RF1, and SNRK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiolipin metabolic process activity versus HOXB13 in COAD (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HOXB13 →	-1.005	-0.126	<.001	.001	3	4
COAD	SH3RF1 →	-0.407	-0.118	.002	.007	3	3
PDAC	SNRK →	-0.248	-0.121	<.001	.003	3	3
GBM	VPS37B →	-0.387	-0.163	<.001	<.001	3	3
UCEC	SUFU →	-0.450	-0.197	.001	<.001	3	3
COAD	PPARGC1B →	-0.469	-0.130	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032048 vs HOXB13 — COAD

Explore this scatter interactively →