Cardiolipin metabolic process

Across TCGA cell cohorts, RNA activity of the Cardiolipin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF3L, TMTC2, and ZMYND8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF3L grouped by Cardiolipin metabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	EIF3L →	+0.653	+1.316	.006	.004	3	4
LIVER	TMTC2 →	-1.818	-1.951	.006	.003	3	4
CNS	ZMYND8 →	+0.787	+0.979	.001	.003	3	4
OVARY	DCLRE1B →	+0.850	+1.433	<.001	<.001	3	4
OVARY	CDCA8 →	+0.673	+1.032	.001	.005	3	4
LUNG_NSCLC_LUAD	APOBEC3B →	+1.501	+0.590	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF3L by Cardiolipin metabolic process activity — LIVER

Explore this box plot interactively →