Cardiolipin metabolic process

Across TCGA cell cohorts, RNA activity of the Cardiolipin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF7, ENKD1, and AREL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiolipin metabolic process activity versus ARHGEF7 in LUNG_NSCLC_LUSC (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ARHGEF7 →	-0.516	-0.234	.003	.005	3	5
LUNG_NSCLC_LUSC	ENKD1 →	-1.612	-0.284	.005	<.001	2	6
KIDNEY	AREL1 →	-0.904	-0.186	.001	.003	3	5
CNS	RIOX1 →	-1.808	-0.233	<.001	<.001	3	4
BLOOD_Leukemia	SMG6 →	-1.148	-0.234	<.001	<.001	3	4
BONE	PDPR →	-0.987	-0.200	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032048 vs ARHGEF7 — LUNG_NSCLC_LUSC

Explore this scatter interactively →