ISG15-protein conjugation

Across TCGA patient cohorts, RNA activity of the ISG15-protein conjugation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAS2, SP110, and PARP9, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ISG15-protein conjugation activity versus OAS2 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OAS2 →	+1.338	+0.113	<.001	.004	3	9
LSCC	SP110 →	+0.591	+0.150	<.001	<.001	3	7
LSCC	PARP9 →	+0.731	+0.166	<.001	<.001	3	7
BRCA	BTN3A3 →	+0.677	+0.101	<.001	.002	3	6
BRCA	ZBP1 →	+1.060	+0.124	<.001	.002	3	6
BRCA	APOL3 →	+0.892	+0.118	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032020 vs OAS2 — BRCA

Explore this scatter interactively →