Negative regulation of TOR signaling

Across TCGA patient cohorts, RNA activity of the Negative regulation of TOR signaling pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMBL, RPL14P6, and ELN-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of TOR signaling activity versus CMBL in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CMBL →	+0.833	+0.213	.001	.002	3	4
CCRCC	RPL14P6 →	+0.244	+0.355	.005	.005	3	3
BRCA	ELN-AS1 →	+0.803	+0.250	<.001	<.001	3	3
BRCA	CBWD2 →	+0.376	+0.321	<.001	.003	3	3
BRCA	SKA3 →	-0.571	-0.247	.009	<.001	3	3
BRCA	TP53TG1 →	+0.376	+0.258	.009	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032007 vs CMBL — BRCA

Explore this scatter interactively →